Guineensine, an Acyl-CoA: Cholesterol Acyltransferase Inhibitor, from the Fruits of Piper longum

Seung Woong Lee; Mun-Chual Rho; Jung Yeon Nam; Eun Hee Lim; Oh Eok Kwon; Young Ho Kim; Hyun Sun Lee; Young Kook Kim

doi:10.1055/s-2004-827193

Planta Med 2004; 70(7): 678-679
DOI: 10.1055/s-2004-827193

Letter

Guineensine, an Acyl-CoA: Cholesterol Acyltransferase Inhibitor, from the Fruits of Piper longum

Seung Woong Lee¹ , Mun-Chual Rho¹ , Jung Yeon Nam¹ , Eun Hee Lim¹ , Oh Eok Kwon¹ , Young Ho Kim² , Hyun Sun Lee¹ , Young Kook Kim¹

¹Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
²College of Pharmacy, Chungnam National University, Taejon, Korea

This research was supported by a grant from Plant Diversity Research Center of 21st Century Frontier Research Program funded by Ministry of Science and Technology of Korean government, and by a grant of KRIBB Research Initiative Program.

Abstract

Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl₃ extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC₅₀ value of 3.12 µM.

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Dr. Young Kook Kim

Laboratory of Lipid Metabolism

Korea Research Institute of Bioscience and Biotechnology

52 Oun-dong

Yusong-gu

Taejon 305 - 333

Korea

Phone: +82-42-860-4556

Fax: +82-42-861-2675

Email: kimyk@kribb.re.kr