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Planta Med 2004; 70(7): 678-679
DOI: 10.1055/s-2004-827193
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Guineensine, an Acyl-CoA: Cholesterol Acyltransferase Inhibitor, from the Fruits of Piper longum

Seung Woong Lee1 , Mun-Chual Rho1 , Jung Yeon Nam1 , Eun Hee Lim1 , Oh Eok Kwon1 , Young Ho Kim2 , Hyun Sun Lee1 , Young Kook Kim1
  • 1Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
  • 2College of Pharmacy, Chungnam National University, Taejon, Korea
This research was supported by a grant from Plant Diversity Research Center of 21st Century Frontier Research Program funded by Ministry of Science and Technology of Korean government, and by a grant of KRIBB Research Initiative Program.
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Publikationsverlauf

Received: January 20, 2004

Accepted: February 22, 2004

Publikationsdatum:
15. Juli 2004 (online)

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Abstract

Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl3 extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC50 value of 3.12 µM.

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Dr. Young Kook Kim

Laboratory of Lipid Metabolism

Korea Research Institute of Bioscience and Biotechnology

52 Oun-dong

Yusong-gu

Taejon 305 - 333

Korea

Telefon: +82-42-860-4556

Fax: +82-42-861-2675

eMail: kimyk@kribb.re.kr