New Cytotoxic Alkyl Phloroglucinols from Protorhus thouvenotii

Shugeng Cao; Jennifer K. Schilling; Armand Randrianasolo; Rabodo Andriantsiferana; Vincent E. Rasamison; David G. I. Kingston

doi:10.1055/s-2004-827195

Planta Med 2004; 70(7): 683-685
DOI: 10.1055/s-2004-827195

Letter

New Cytotoxic Alkyl Phloroglucinols from Protorhus thouvenotii

Shugeng Cao¹ , Jennifer K. Schilling¹ , Armand Randrianasolo² , Rabodo Andriantsiferana³ , Vincent E. Rasamison³ , David G. I. Kingston¹

¹Department of Chemistry M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
²Missouri Botanical Garden, St. Louis, Missouri, USA
³Centre National d'Application et Recherches Pharmaceutiques, Antananarivo, Madagascar

Biodiversity Conservation and Drug Discovery in Madagascar, Part 11. For Part 10, see ref. 1

Abstract

Two new cytotoxic alkylene phloroglucinols and one known compound were isolated through chromatographic separation from the methanolic extract of the dried fruits of Protorhus thouvenotii (Anacardiaceae). The compounds showed marginal in vitro cytotoxicity in the A2780 ovarian cancer cell line assay with an IC₅₀ of 11 μg/mL.

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References

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Dr. David G. I. Kingston

Department of Chemistry

M/C 0212

Virginia Polytechnic Institute and State University

Blacksburg

Virginia 24061

USA

Phone: +1-540-231-6570

Fax: +1-540-231-3255

Email: dkingston@vt.edu