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DOI: 10.1055/s-2004-827235
© Georg Thieme Verlag KG Stuttgart · New York
In vitro Antiviral Diterpenes from the Brazilian Brown Alga Dictyota pfaffii
Publication History
Received: December 12, 2003
Accepted: May 20, 2004
Publication Date:
23 September 2004 (online)
![](https://www.thieme-connect.de/media/plantamedica/200409/lookinside/thumbnails/10.1055-s-2004-827235-1.jpg)
Abstract
Specimens of Dictyota pfaffii from Atol das Rocas, Northeast Brazil, afforded the rare dolabellane diterpene 10,18-diacetoxy-8-hydroxy-2, 6-dolabelladiene (1) and the new 10-acetoxy-8,18-dihydroxy-2,6-dolabelladiene (2). Reduction of 1 yielded 8,10,18-trihydroxy-2,6-dolabelladiene (3), also present in the crude extract of D. pfaffii. All three structures were assigned by 1D and 2D NMR spectral data. These substances showed strong anti-HSV-1 activity in vitro but only 3 inhibited the reverse transcriptase enzyme of HIV-1.
Key words
Dictyota pfaffii - Dictyotales - dolabellanes - marine diterpenoids - antiviral activity - HSV-1 - HIV-1
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Valéria Laneuville Teixeira
Departamento de Biologia Marinha
Instituto de Biologia
P.O. Box 100.644
Universidade Federal Fluminense
Niterói, 24001-970
RJ
Brazil
Phone: +55-21-26292311
Fax: +55-21-26292292
Email: gbmvalt@vm.uff.br