Abstract
A new β-hydroxy-γ-methyl-γ-lactone bistetrahydrofuranic acetogenin, tucumanin, with the infrequent symmetrical threo/trans/threo/trans/threo relative configuration at the tetrahydrofuran rings was isolated from Annona cherimolia (Annonaceae) seeds. The inhibitory potency on the mitochondrial complex I of acetogenins with this relative configuration (tucumanin and asimicin) was compared with that shown by the corresponding pairs with an asymmetrical threo/trans/threo/trans/erythro relative configuration (laherradurin/rolliniastatin-2, and itrabin/molvizarin). All these compounds act as selective inhibitors of mitochondrial complex I in the 0.18 - 1.55 nM range.
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Prof. Dr. M. Carmen Zafra-Polo
Departamento de Farmacología
Facultad de Farmacia
Avda. Vicent Andrés Estellés s/n
46100 Burjassot
Valencia
Spain
Phone: +34-96-354-4944
Fax: +34-96-354-4943
Email: carmen.zafra@uv.es
