A Practical Synthesis of N-Substituted 1,2-Benzisothiazolin-3-ones from N,N′-Disubstituted 2,2′-Dithiodibenzamides

Tomohumi Sano; Toshiyuki Takagi; Yasuo Gama; Isao Shibuya; Masao Shimizu

doi:10.1055/s-2004-829101

PAPER

A Practical Synthesis of N-Substituted 1,2-Benzisothiazolin-3-ones from N,N′-Disubstituted 2,2′-Dithiodibenzamides

Tomohumi Sano, Toshiyuki Takagi, Yasuo Gama, Isao Shibuya, Masao Shimizu*
National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan
Fax: +81(29)8614487; e-Mail: m.shimizu@aist.go.jp;

Abstract

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Abstract

A variety of N-substituted 1,2-benzisothiazolin-3-ones were easily synthesized from N,N′-disubstituted 2,2′-dithiodibenzamides in the presence of O-methylhydroxylamine hydrochloride. Derivatives with a primary, secondary, or tertiary alkyl group or an aryl group on the N-1 nitrogen of the 1,2-benzisothiazolin-3-one were obtained.

Key words

benzisothiazoles - disulfides - amides - hydroxylamines - oximes

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References

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