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Synthesis 2004(10): 1533-1553
DOI: 10.1055/s-2004-829106
DOI: 10.1055/s-2004-829106
REVIEW
© Georg Thieme Verlag Stuttgart · New York
Synthetic Methodologies for C-Nucleosides
Further Information
Received
26 February 2004
Publication Date:
23 June 2004 (online)
Publication History
Publication Date:
23 June 2004 (online)
Abstract
The study and synthesis of C-nucleosides has been extensive owing to their biological activity and potential as drug candidates for antiviral and anticancer therapy. Numerous synthetic strategies have also been investigated in order to optimize yields and stereoselectivity in the glycosylation reaction. Here we review one class of synthetic methods, direct condensation of a pre-formed aglycon unit with an appropriate sugar component.
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1 Introduction
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2 Coupling of Ribofuranose Derivatives with Organometallic Reagents
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3 Heck-Type Coupling Reaction
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4 Coupling of Protected Ribofuranosyl Chlorides with Organometallic Reagents
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5 Coupling of 1,4-Ribonolactone Derivatives with Organometallic Reagents
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6 Coupling Reactions Mediated by Lewis Acids
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7 Conclusions
Key words
C-nucleosides - organometallic reagents - Heck-type reaction - anticancer - antiviral
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