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Synthesis 2004(10): 1664-1670
DOI: 10.1055/s-2004-829114
DOI: 10.1055/s-2004-829114
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Convenient Synthesis of 4-Alkoxylated Isoindolin-1-ones
Further Information
Received
22 January 2004
Publication Date:
23 June 2004 (online)
Publication History
Publication Date:
23 June 2004 (online)
Abstract
A short synthesis of 4-alkoxylated isoindolin-1-ones based upon the SNAr reaction applied to phosphorylated 2-methoxybenzamides followed by alkaline cleavage of the phosphoryl auxiliary is reported.
Key words
metalations - carbanions - nucleophilic aromatic substitutions - ring closure - cleavage
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