Abstract
New purinyl 2′,3′-dihomo-xylo -carbocyclic pentafuranosides and carbocyclic nucleosides fused with tetrahydrofuran ring were synthesized from (±)-c -4-amino-r -1,c -2,t -3-cyclopentanetrimethanol (8 ). The strongly acid medium in which the purine system was completed on pyrimidine derivative 9 caused condensation of the cis -hydroxymethyl groups, giving rise to a 3-oxabicyclo[3.3.0]octane structure. None of the new compounds exhibited more than very modest antiviral or antitumor activity.
Key words
xylo -carbocyclic nucleosides - tetrahydrofuran derivatives - synthesis - antiviral - antitumoral activity
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