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Synthesis 2004(12): 1929-1931
DOI: 10.1055/s-2004-829156
DOI: 10.1055/s-2004-829156
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of 1,3,4-Thiadiazoles from Aldehyde Hydrazones
Further Information
Received
18 March 2004
Publication Date:
21 July 2004 (online)
Publication History
Publication Date:
21 July 2004 (online)
Abstract
Reaction of p-tolualdehyde hydrazone with disulfur dichloride in the presence of DBU gave 2,5-di (p-tolyl)-1,3,4-thiadiazole (1a) in 54% yield. Phenyldiazomethane also reacted with disulfur dichloride to afford 2,5-diphenyl-1,3,4-thiadiazole (1b) in 80% yield.
Key words
hydrazone - disulfur dichloride - 1,3,4-thiadiazole - phenyldiazomethane
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