Solvent-Free Synthesis of Chiral N,N′-Disubstituted Thioureas by ‘Just Mixing’ the Reagents

Abstract

The synthesis of new chiral thioureas 3a-f by using the ecofriendly solvent-free and microwave-assisted approaches is reported and, unexpectedly, in the former method by just mixing the starting materials the products are instantaneously obtained. The crystal structures for 3b, 3c and 3e are also reported.

Key words

chiral thioureas - green-chemistry - crystallographic analysis

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XSCAnS (release 2.21) Users Manual, Siemens Analytical X-ray Instruments Inc.: Madison, WI, 1996.