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Synthesis 2004(13): 2091-2093
DOI: 10.1055/s-2004-829170
DOI: 10.1055/s-2004-829170
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Iodine Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and Thiones: A Simple and Efficient Procedure for the Biginelli Reaction [1]
Further Information
Received
14 April 2004
Publication Date:
27 July 2004 (online)
Publication History
Publication Date:
27 July 2004 (online)
![](https://www.thieme-connect.de/media/synthesis/200413/lookinside/thumbnails/10.1055-s-2004-829170-1.jpg)
Abstract
Iodine efficiently catalyzes the Biginelli reaction. This procedure involves a one-pot three-component cyclocondensation of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or thiones in high yields.
Keywords
iodine - aldehydes - 1,3-dicarbonyl compounds - urea - thiourea - one-pot condensation - dihydropyrimidin-ones and thiones - Biginelli reaction
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