Download PDF
Synthesis 2004(13): 2115-2120  
DOI: 10.1055/s-2004-829172
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis and Reactions of Paramagnetic Aromatic Aldehydes as Useful Synthetic Building Blocks

Tamás Kálaia, Győző Kulcsára, József Jekőb, Erzsébet Őszc, Kálmán Hideg*a
a Institute of Organic and Medicinal Chemistry, University of Pécs, P. O. Box 99, 7602 Pécs, Hungary
Fax: +36(72)536219; e-Mail: kalman.hideg@aok.pte.hu;
b ICN Hungary, P. O. Box 1, 4440 Tiszavasvári, Hungary
c Department of Biochemistry and Medical Chemistry, University of Pécs, P. O. Box 99, 7602 Pécs, Hungary
Further Information

Publication History

Received 6 May 2004
Publication Date:
27 July 2004 (online)

    Permissions and Reprints All articles of this category

Abstract

Starting from paramagnetic benzaldehyde, a benzophenone-type photoactivable spin label, paramagnetic warfarin and phenindione were synthesized. Nitration of protected benzylic alcohol led to 2-nitrobenzylmethanethiosulfonate, a thiol specific spin label, and 2-nitroaldehyde, which was a key compound for paramagnetic indigo, salicylic acid and nifedipine.

Key words

anticoagulant - free radicals - drugs - indole - pyridines