Abstract
A new rat model of the sacrifice of the anterior and posterior cortical anastomotic
veins by the microsurgical technique was used to evaluate venous infarction. 20 male
Sprague-Dawley rats were used in this experiment. Small burr-holes were done over
the anterior and posterior anastomotic veins. After the precise description of these
vessels, bipolar coagulation and micro-scissor was used for sacrifice. Specimens were
evaluated by histopathological techniques. Hemispheric swelling, midline shift, brain
edema, subcortical petechial hemorrhage, infarction and necrosis were histopathological
findings on the microscopic examination. Our results revealed that the sacrifice of
the anterior and posterior anastomotic veins was a very successful model in the evaluation
of brain damage after the disturbance to the venous circulation.
Key words
Cerebral veins - anastomotic veins - brain swelling - venous ischemia - rat venous
ischemia model
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Cengiz Çokluk, M.D.
Department of Neurosurgery · Medical Faculty · Ondokuzmayıs University
55139 Samsun
Turkey
Phone: + 90-362-457-6000/3086 int.
Fax: + 90-362-457-6041 ·
Email: cengizcokluk@yahoo.com
