Int J Sports Med 2005; 26(1/02): 79-81
DOI: 10.1055/s-2004-830450
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© Georg Thieme Verlag KG Stuttgart · New York

Total and Free PSA Serum Concentrations are not Influenced by Extensive Physical Exercise and Bicycle Riding

G. Lippi1 , A. Corgnati1 , G. Salvagno1 , F. Schena2 , M. Franchini3 , G. Guidi1
  • 1Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Verona, Italy
  • 2Centro Interuniversitario di Ricerca in Bioingegneria e Scienze Motorie, Rovereto (TN), Italy
  • 3Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
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Publikationsverlauf

Accepted after revision: September 30, 2004

Publikationsdatum:
05. Januar 2005 (online)

Abstract

Vigorous and prolonged physical exercise and mechanical involvement of the perineal region might influence prostatic function and measurement of both total (PSA) and free prostate specific antigen (fPSA), decreasing the diagnostic efficiency of the laboratory screening for either benign or neoplastic prostate disorders in athletes. To investigate the effects of regular and strenuous physical exercise with or without bicycle riding on integrity and biochemical function of prostatic tissue, we measured serum PSA and fPSA in 69 elite and professional cyclists, 31 members of the Italian national cross-country ski team, and in 43 sedentary healthy controls. The concentration of both PSA and fPSA did not differ significantly between sedentary individuals and physically active cross-country skiers (PSA 0.43 ± 0.30 vs. 0.36 ± 0.25, ns; fPSA 0.16 ± 0.12 vs. 0.12 ± 0.12, ns) or cyclists (PSA 0.43 ± 0.30 vs. 0.36 ± 0.23, ns; fPSA 0.16 ± 0.12 vs. 0.13 ± 0.08, ns), and the relative distribution of values appeared almost overlapping. We hypothesize that neither a heavy and regular physical exercise nor the extensive and prolonged mechanical involvement of the prostate region by the bicycle riding have significant influence on release of both PSA and fPSA.

References

  • 1 Banfi G, Pontillo M, Dolci A, Roi G S. Prostate-specific antigen is not increased in young men by ultraendurance sport performances.  Clin Chem. 1997;  43 1465-1466
  • 2 Bunting P S. Screening for prostate cancer with prostate-specific antigen: beware the biases.  Clin Chim Acta. 2002;  315 71-97
  • 3 Cronauer M V, Schulz W A, Burchardt T, Anastasiadis A G, de la Taille A, Ackermann R, Burchardt M. The androgen receptor in hormone-refractory prostate cancer: Relevance of different mechanisms of androgen receptor signaling.  Int J Oncol. 2003;  23 1095-1102
  • 4 Dixon S C, Knopf K B, Figg W D. The control of prostate-specific antigen expression and gene regulation by pharmacological agents.  Pharmacol Rev. 2001;  53 73-91
  • 5 Hackney A C, Szczepanowska E, Viru A M. Basal testicular testosterone production in endurance-trained men is suppressed.  Eur J Appl Physiol. 2003;  89 198-201
  • 6 Harris R, Lohr K N. Screening for prostate cancer: an update of the evidence for the U. S. Preventive Services Task Force.  Ann Intern Med. 2002;  137 917-929
  • 7 Luboldt H J, Peck K D, Oberpenning F, Schmid H P, Semjonow A. Bicycle riding has no important impact on total and free prostate-specific antigen serum levels in older men.  Urology. 2003;  61 1177-1180
  • 8 Mackenzie S H, Safford H R, Capriola M. The effect of bicycle riding on serum prostate specific antigen levels.  J Urol. 1996;  156 103-105
  • 9 Mokete M, Palmer A R, O'Flynn K J. High result in prostate specific antigen test.  BMJ. 2003;  327 379
  • 10 Nadler R B, Humphrey P A, Smith D S, Catalona W J, Ratliff T L. Effect of inflammation and benign prostatic hyperplasia on elevated serum prostate specific antigen levels.  J Urol. 1995;  154 407-413
  • 11 Oremek G M, Seiffert U B. Physical activity releases prostate-specific antigen (PSA) from the prostate gland into blood and increases serum PSA concentrations.  Clin Chem. 1996;  42 691-695
  • 12 Rosenberg Zand R S, Jenkins D J, Diamandis E P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression.  Clin Chim Acta. 2001;  312 213-219

MD Giuseppe Lippi

Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Ospedale Policlinico G.B. Rossi,

Piazzale Scuro, 10

37134 Verona

Italy

Telefon: + 390458074516

Fax: + 39 04 58 20 18 89

eMail: ulippi@tin.it