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Exp Clin Endocrinol Diabetes 2005; 113(2): 67-79
DOI: 10.1055/s-2004-830555
Review

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Adipocytokines: Fat-Derived Humoral Mediators of Metabolic Homeostasis

H. Staiger1 , H.-U. Häring1
  • 1Department of Endocrinology, Metabolism, and Pathobiochemistry, Medical Clinic Tübingen, Eberhard-Karls-University, Tübingen, Germany
Further Information

Publication History

Received: June 21, 2004 First decision: July 21, 2004

Accepted: September 9, 2004

Publication Date:
17 March 2005 (online)

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Abstract

The metabolic syndrome currently reaches epidemic proportions in the Western industrialized world. Its hallmarks obesity, type 2 diabetes mellitus, and atherosclerosis are closely associated, and we are just beginning to understand the reasons for this relationship: adipose tissue-derived proteohormones (adipocytokines), under normal weight conditions, guarantee homeostasis of glucose and lipid metabolism, but their dysregulated production in the obese state promotes insulin resistance, inflammation, as well as atherosclerotic events. This review will focus on the current understanding of the adipocytokines' molecular role in metabolism and metabolic disease.

Key words

Adipocytokines - insulin sensitivity - metabolism - obesity

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Prof. Dr. med. Hans-Ulrich Häring

Department of Internal Medicine IV, Medical Clinic Tübingen

Otfried-Müller-Straße 10

72076 Tübingen

Germany

Phone: + 4970712982735

Fax: + 49 70 71 29 27 84

Email: hans-ulrich.haering@med.uni-tuebingen.de