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Synthesis 2004(15): 2550-2554  
DOI: 10.1055/s-2004-831179
PAPER
© Georg Thieme Verlag Stuttgart · New York

Baylis-Hillman Reaction Assisted Synthesis of Substituted 5,8-Dihydroisoxazolo[4,5-c]azepin-4-ones: A Novel Isoxazole-Annulated Heterocycle [1]

Sanjay Batra*, Amrendra K. Roy
Medicinal Chemistry Division, Central Drug Research Institute, PO Box 173, Lucknow-226001, India
Fax: +91(522)2223405, +91(522)2223938; e-Mail: batra_san@yahoo.co.uk;
Further Information

Publication History

Received 21 May 2004
Publication Date:
19 August 2004 (online)

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Abstract

The novel synthesis of a new isoxazole-annulated heterocycle namely, 5,8-dihydroisoxazolo[4,5-c]azepin-4-one, described herein is based on the reaction of benzylamine with acetates of Baylis-Hillman adducts generated from 3-aryl-5-formyl-isoxazole-4-carboxylate.

Key words

Baylis-Hillman reaction - acetates - 3-aryl-5-formyl-isoxazole-4-carboxylates - 5,8-dihydroisoxazole[4,5-c]azepine-4-ones

1

CDRI Communication No 6510.

1

CDRI Communication No 6510.