Baylis-Hillman Reaction Assisted Synthesis of Substituted 5,8-Dihydroisoxazolo[4,5-c]azepin-4-ones: A Novel Isoxazole-Annulated Heterocycle [1]

Abstract

The novel synthesis of a new isoxazole-annulated heterocycle namely, 5,8-dihydroisoxazolo[4,5-c]azepin-4-one, described herein is based on the reaction of benzylamine with acetates of Baylis-Hillman adducts generated from 3-aryl-5-formyl-isoxazole-4-carboxylate.

Baylis-Hillman reaction - acetates - 3-aryl-5-formyl-isoxazole-4-carboxylates - 5,8-dihydroisoxazole[4,5-c]azepine-4-ones

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