With regard to green chemistry, atom-efficient transformations of easily available
starting materials into complex organic building blocks become increasingly important.
Here, a novel four-component condensation of ninhydrin, 1,2-phenylene diamine, proline
and N-aryl maleimides to some new spiro pyrrolizidines via 1,3-dipolar cycloadditions of
azomethine ylides, under microwave irradiation or classical conditions, is reported.
spiro pyrrolizidines - azomethine ylides - 1,3-dipolar cycloadditions
