Abstract
New amphiphilic nucleosides 3 , 5 , 7 , 9 and nucleobases 12 , 14 , with lipophilic alkynyl substituents attached to the N-heterocyclic ring were obtained in a straightforward manner by Sonogashira coupling of 5-iodouridine, 8-bromoadenosine and protected 8-bromoguanosine or related halonucleobases. In most cases protective groups were unnecessary.
Key words
nucleosides - nucleobases - cross-coupling - amphiphile - alkynes
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