Chemoselective Deprotection of Allylic Amines Catalyzed by Grubbs’ Carbene

Abstract

A commercially available ruthenium complex (first generation Grubbs’ carbene) was used for the catalytic deprotection of allylic amines (secondary as well as tertiary), by using for the first time reagents different from palladium catalysts. Interestingly, the catalytic system directs the reaction toward the selective deprotection of allylamines in the presence of allylic ethers.

Key words

amines - carbenes - catalytic cleavage - protecting groups - ruthenium

References

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