Abstract
The synthesis of a new series of 1,2-disubstituted carbonucleosides analogues of pyrimidine (cyclohexane derivatives) is reported. For the synthesis of the uridine analogue 5a , either construction of the base on the amino group of the amino alcohol 3 or on the amido group of the predecessor β-lactam 1 was more efficient than condensation of the base with a protected diol. The cis -configuration of 5a was confirmed by X-ray crystallography. Compound 5a was halogenated with Cl, Br and I at uracil position 5.
Key words
amino alcohols - cyclizations - heterocycles - Mitsunobu reaction - nucleosides
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