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DOI: 10.1055/s-2004-831226
Free Radical-Mediated Aryl Amination: A Practical Synthesis of (R)- and (S)-7-Azaindoline α-Amino Acid
Publication History
Publication Date:
16 September 2004 (online)
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Abstract
Two nonnatural proline derivatives, (S)- and (R)-7-azaindoline α-amino acid have been prepared and isolated as their trifluoroacetate salt on gram scale. The convergent sequence (6 steps from 2-bromopyridine) employs a combination of enantioselective phase transfer catalyzed glycine alkylation and free radical-mediated aryl amination. Implementation of the solid-liquid phase transfer conditions requires manual pulverization of cesium hydroxide, efficient mechanical stirring, and effective low temperature control. This large scale free radical cyclization protocol replaces benzene solvent with toluene without complication, and the crystalline nature of the intermediates and final product enables straightforward purification at each stage, including enantiomeric enrichment (89% to >99% ee for 4b, Scheme [1] ).
Key words
free radical cyclization - aryl amination - α-amino acid - enantioselective synthesis - phase-transfer catalysis
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References
In our hands, a noticeable improvement of enantioselection is observed for this transformation if the crystalline ammonium salt is chromatographed (ref.1a).