N-Acylation of 5-Substituted Indoles with Carboxylic Acids via DCC Coupling

John B. Bremner; Siritron Samosorn; Joseph I. Ambrus

doi:10.1055/s-2004-831228

PAPER

N-Acylation of 5-Substituted Indoles with Carboxylic Acids via DCC Coupling

John B. Bremner*, Siritron Samosorn, Joseph I. Ambrus
Institute for Biomolecular Science and Department of Chemistry, University of Wollongong, N.S.W. 2522, Australia
Fax: +61(2)42214287; e-Mail: john_bremner@uow.edu.au;

Abstract

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Abstract

A method for the N-acylation of 5-substituted indoles with carboxylic acids using DCC and DMAP is presented. High yields were obtained when an electron-withdrawing group was present at C-5, however the method was less effective with a C-5 electron-donating group.

Key words

N-acylation - indoles - carboxylic acids - DCC coupling - DMAP

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References

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