N-Acylation of 5-Substituted Indoles with Carboxylic Acids via DCC Coupling

Abstract

A method for the N-acylation of 5-substituted indoles with carboxylic acids using DCC and DMAP is presented. High yields were obtained when an electron-withdrawing group was present at C-5, however the method was less effective with a C-5 electron-donating group.

N-acylation - indoles - carboxylic acids - DCC coupling - DMAP

References

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