Inhibin is a dimeric (α and either βA or βB subunit) protein involved in the regulation of fertility. Inhibin A and B or its free α subunit monomer are elevated in various gonadal and prostate cancers and thus serve as useful diagnostic tools for certain ovarian tumors either as a serum marker or as an immunocytochemical marker for tissue sections. Serum inhibin levels are of value in the initial diagnosis and subsequent follow-up of sex cord stromal tumors, in particular granulosa cell tumors, and mucinous epithelial adenocarcinomas primarily after menopause. Immunocytochemistry using inhibin α subunit antisera can aid in the classification of sex cord stromal tumors and their differentiation from other cancers. Although serum inhibins are elevated in prostatic and testicular cancers, this is of little diagnostic value at the present time.
KEYWORDS
Ovarian cancer - granulosa cell tumors - mucinous carcinomas - inhibin α subunit - prostate cancer
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David M RobertsonPh.D.
Prince Henry's Institute of Medical Research
P.O. Box 5152, Clayton
Victoria 3168, Australia
