Zentralbl Gynakol 2004; 126(5): 326-327
DOI: 10.1055/s-2004-832303
Originalarbeit

© Georg Thieme Verlag Stuttgart · New York

Prognostische Relevanz und Regulation der Cyclooxygenase-2 (COX-2) im Ovarialkarzinom

Prognostic Role and Regulation of Cyclooxygenase-2 (COX-2) in Ovarian CarcinomaC. Denkert1
  • 1Institut für Pathologie, Universitätsklinikum Charité, Berlin
Further Information

Publication History

Publication Date:
20 October 2004 (online)

Literatur

  • 1 Thun M J, Namboodiri M M, Heath C W. Aspirin use and reduced risk of fatal colon cancer.  N Engl J Med. 1991;  325 1593-1596
  • 2 Khuder S A, Mutgi A B. Breast cancer and NSAID use: a meta-analysis.  Br J Cancer. 2001;  84 1188-1192
  • 3 Hial V, Horakova Z, Shaff F E, Beaven M A. Alteration of tumor growth by aspirin and indomethacin: studies with two transplantable tumors in mouse.  Eur J Pharmacol. 1976;  37 367-376
  • 4 Kudo T, Narisawa T, Abo S. Antitumor activity of indomethacin on methylazoxymethanol-induced large bowel tumors in rats.  Gann. 1980;  71 260-264
  • 5 Boolbol S K, Dannenberg A J, Chadburn A, Martucci C, Guo X J, Ramonetti J T, Abreu-Goris M, Newmark H L, Lipkin M L, DeCosse J J, Bertagnolli M M. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.  Cancer Res. 1996;  56 2556-2560
  • 6 Sawaoka H, Kawano S, Tsuji S, Tsujii M, Gunawan E S, Takei Y, Nagano K, Hori M. Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude mice.  Am J Physiol. 1998;  274 G1061-G1067
  • 7 Sheng H, Shao J, Kirkland S C, Isakson P, Coffey R J, Morrow J, Beauchamp R D, DuBois R N. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.  J Clin Invest. 1997;  99 2254-2259
  • 8 Denkert C, Köbel M, Pest S, Koch I, Berger S, Schwabe M, Siegert A, Reles A, Klosterhalfen B, Hauptmann S. Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma.  Am J Pathol. 2002;  160 893-903
  • 9 Denkert C, Fürstenberg A, Daniel P T, Koch I, Köbel M, Weichert W, Siegert A, Hauptmann S. Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2 specific RNA interference.  Oncogene. 2003;  22 8653-8661
  • 10 Seo S S, Song Y S, Kang D H, Park I A, Bang Y J, Kang S B, Lee H P. Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in epithelial ovarian cancer.  Gynecol Oncol. 2004;  92 927-935
  • 11 Raspollini M R, Amunni G, Villanucci A, Boddi V, Baroni G, Taddei A, Taddei G L. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in ovarian cancer: correlation with clinical outcome.  Gynecol Oncol. 2004;  92 806-812
  • 12 Erkinheimo T L, Lassus H, Finne P, van Rees B P, Leminen A, Ylikorkala O, Haglund C, Butzow R, Ristimaki A. Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma.  Clin Cancer Res. 2004;  10 538-545

Carsten Denkert

Institut für Pathologie, Universitätsklinikum Charité, Berlin

Schumannstr. 20/21

10117 Berlin

Phone: 0 30/4 50-5 36-0 47

Fax: 0 30/4 50-5 36-9 00

Email: carsten.denkert@charite.de