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Zentralbl Gynakol 2004; 126(5): 326-327
DOI: 10.1055/s-2004-832303
DOI: 10.1055/s-2004-832303
Originalarbeit
© Georg Thieme Verlag Stuttgart · New York
Prognostische Relevanz und Regulation der Cyclooxygenase-2 (COX-2) im Ovarialkarzinom
Prognostic Role and Regulation of Cyclooxygenase-2 (COX-2) in Ovarian CarcinomaFurther Information
Publication History
Publication Date:
20 October 2004 (online)
Schlüsselwörter
Cyclooxygenase-2 - molekulare Prognosefaktoren - Ovarialkarzinom
Key words
Cyclooxygenase-2 - molecular prognostic factors - ovarian carcinoma
Literatur
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- 7 Sheng H, Shao J, Kirkland S C, Isakson P, Coffey R J, Morrow J, Beauchamp R D, DuBois R N. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest. 1997; 99 2254-2259
- 8 Denkert C, Köbel M, Pest S, Koch I, Berger S, Schwabe M, Siegert A, Reles A, Klosterhalfen B, Hauptmann S. Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma. Am J Pathol. 2002; 160 893-903
- 9 Denkert C, Fürstenberg A, Daniel P T, Koch I, Köbel M, Weichert W, Siegert A, Hauptmann S. Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2 specific RNA interference. Oncogene. 2003; 22 8653-8661
- 10 Seo S S, Song Y S, Kang D H, Park I A, Bang Y J, Kang S B, Lee H P. Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in epithelial ovarian cancer. Gynecol Oncol. 2004; 92 927-935
- 11 Raspollini M R, Amunni G, Villanucci A, Boddi V, Baroni G, Taddei A, Taddei G L. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in ovarian cancer: correlation with clinical outcome. Gynecol Oncol. 2004; 92 806-812
- 12 Erkinheimo T L, Lassus H, Finne P, van Rees B P, Leminen A, Ylikorkala O, Haglund C, Butzow R, Ristimaki A. Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma. Clin Cancer Res. 2004; 10 538-545
Carsten Denkert
Institut für Pathologie, Universitätsklinikum Charité, Berlin
Schumannstr. 20/21
10117 Berlin
Phone: 0 30/4 50-5 36-0 47
Fax: 0 30/4 50-5 36-9 00
Email: carsten.denkert@charite.de