Pharmacopsychiatry 2004; 37(5): 239-240
DOI: 10.1055/s-2004-832600
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Olanzapine Augmentation in Panic Disorder

A Case ReportI.-L. Chao1
  • 1Department of Psychiatry, Taipei Veteran’s General Hospital, Taipei, Taiwan
Further Information

Publication History

Received: 30.4.2003 Revised: 17.7.2003

Accepted: 15.9.2003

Publication Date:
10 September 2004 (online)

Chronic and treatment refractory cases of panic disorder are not uncommon. We report on a man completely remitted from panic disorder after olanzapine and paroxetine combined treatment, and the possible modulating anti-anxiety effect of olanzapine is discussed. Olanzapine augmentation in panic and other anxiety disorders is deserving of more clinical attention.

References

  • 1 Etxebeste M, Aragues E, Malo P, Pacheco L. Olanzapine and panic attacks.  Am J Psychiatry. 2000 Apr;  157(4) 659-60
  • 2 Mathew S J, Coplan J D, Gorman J M. Management of treatment-refractory panic disorder.  Psychopharmacol Bull. 2001 Spring;  35(2) 97-110
  • 3 Nyberg S, Farde L, Halldin C. A PET study of 5-HT2 and D2 dopamine receptor occupancy induced by olanzapine in healthy subjects.  Neuropsychopharmacology. 1997;  16 1-7
  • 4 Roy-Byrne P P, Cowley D S. Course and outcome in panic disorder: a review of recent follow-up studies.  Anxiety. 1994 - 1995;  1(4) 151-60
  • 5 Shelton R C, Tollefson G D, Tohen M ,. et al . A novel augmentation strategy for treating resistant major depression.  Am J Psychiatry. 2001;  158 31-134
  • 6 Work Group on Panic D isorder, American Psychiatric A ssociation. Practice guideline for the treatment of patients with panic disorder.  Am J Psychiatry. 1998 May;  155(5 Suppl) 1-34

Iou-Lin Chao, M.D.

Department of Psychiatry

Taipei Veteran’s General Hospital

Taipei

Taiwan

Email: ilchao@vghtpe.gov.tw