Planta Med 2004; 70(10): 893-896
DOI: 10.1055/s-2004-832612
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Constituents of the Seeds of Hernandia ovigera with Inhibitory Activity against Cyclooxygenase-2

Dae Sik Jang1 , 3 , Muriel Cuendet1 , Bao-Ning Su1 , 4 , Steven Totura1 , Soedarsono Riswan2 , Harry H. S. Fong1 , John M. Pezzuto1 , 5 , A. Douglas Kinghorn1 , 4
  • 1Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, IL, USA
  • 2Herbarium Bogoriense, Research Center for Chemistry, Indonesian Institute of Science, Serpong, Tangerang, Indonesia
  • 3Present address: College of Pharmacy, Ewha Womans University, Seoul, Korea
  • 4Present address: College of Pharmacy, The Ohio State University, Columbus, Ohio, USA
  • 5Present address: Heine Pharmacy Building, Purdue University, West Lafayette, Indiana, USA
Weitere Informationen

Publikationsverlauf

Received: April 5, 2004

Accepted: July 5, 2004

Publikationsdatum:
18. Oktober 2004 (online)

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Abstract

A new dibenzylbutyrolactone lignan, (2R,3R)-5′-methoxyguayarol (1), was isolated from an EtOAc-soluble extract of the seeds of Hernandia ovigera using an in vitro activity-guided fractionation procedure based on the inhibition of cyclooxygenase-2. Also obtained were three known fatty acid derivatives, (S)-coriolic acid, (±)-12,13-epoxyoleic acid, and (±)-glycerol 1-monolinolate, and seven known lignans, epiashantin, dehydrodesoxypodophyllotoxin, dehydropodophyllotoxin, (-)-hernolactone, (-)-pinoresinol, (-)-syringaresinol, and (-)-yatein. The structure, including absolute stereochemistry, of compound 1 was determined using spectroscopic methods. All isolates were tested for their inhibitory effects against both cyclooxygenases-1 and -2, with (S)-coriolic acid and (±)-glycerol 1-monolinolate shown to have selective inhibitory activity with cyclooxygenase-2.

References

Prof. A. Douglas Kinghorn, Ph. D., D.Sc.

Division of Medicinal Chemistry and Pharmacognosy

College of Pharmacy

The Ohio State University

500 West 12th Street

Columbus

OH 43210

USA

Telefon: +1-614-247-8094

Fax: +1-614-247-8081

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