Zusammenfassung
Intravenöse Sauerstoffinfusionen werden in der Komplementärmedizin vorwiegend zur Behandlung von entzündlichen Krankheiten, arteriellen Durchblutungsstörungen und neuerdings auch zur Behandlung von malignen Tumoren erfolgreich eingesetzt. Wiederholte Sauerstoffinfusionen führen regelmäßig zu einer Eosinophilie im peripheren Blut. Eosinophile Granulozyten können das Enzym 15-Lipoxygenase-1 produzieren, dem antientzündliche und antikarzinomatöse Effekte zugeschrieben werden. Wir vermuten deshalb eine Beteiligung der 15-Lipoxygenase am Wirkmechanismus der intravenösen Sauerstofftherapie.
Bei 7 Patienten wurde vor, während und nach einer 4-wöchigen täglichen Behandlung mit intravenösen Sauerstoffinfusionen die Anzahl von Eosinophilen im Blut und deren Gehalt an 15-Lipoxygenase-1 bestimmt. Sowohl die Eosinophilenzahl als auch die 15-Lipoxygenase-1 stiegen während der Behandlung gegenüber den Ausgangswerten deutlich an und fielen 2 und 4 Wochen nach Ende der Behandlung wieder ab.
Unsere Ergebnisse zeigen, dass intravenöse Sauerstoffinfusionen die Eosinophilenzahl und deren Gehalt an 15-Lipoxygenase-1 deutlich erhöhen. Hiermit ist ein wesentlicher Wirkmechanismus gefunden, der die Anwendung der intravenösen Sauerstoffbehandlung bei entzündlichen und malignen Erkrankungen rechtfertigt und Anlass zu klinischen Studien gibt.
Abstract
In complementary medicine, intravenous oxygen infusions are used successfully mainly for the treatment of inflammatory diseases, arterial circulatory disturbances and recently also for the treatment of malignant tumors. Repeated oxygen infusions regularly lead to an eosinophilia in the peripheral blood. Eosinophilic granulocytes can produce the enzyme 15-lipoxygenase-1, which is said to have anti-inflammatory and anti-carcinomatoid effects. This is why we suspect an involvement of 15-lipoxygenase in the mode of action of the intravenous oxygen therapy.
During and after a daily treatment, which lasted 4 weeks, with intravenous oxygen infusions, the number of eosinophiles in blood and its content of 15-lipoxygenase-1 was determined in 7 patients. The number of eosinophiles as well as the 15-lipoxygenase-1 increased significantly during the treatment, when compared to the initial values and decreased after 2 and 4 weeks after the end of the treatment.
Our results show that intravenous oxygen infusions lead to a significant increase of the number of eosinophiles and their content of 15-lipoxygenase-1. With this, a significant mode of action has been discovered, which justifies the use of the intravenous oxygen treatment in the case of inflammatory and malignant diseases, and which gives reason for clinical studies.
Schlüsselwörter
Eosinophile Granulozyten - 15-Lipoxygenase - Entzündungshemmung - intravenöse Sauerstofftherapie - Oxyvenierung
Keywords
Eosinophils - 15-lipoxygenase - anti-inflammatory - intravenous oxygen therapie - oxyvenation
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Korrespondenzadresse
Dr. med. Franz Josef Kreutzer
Facharzt für Innere Krankheiten
Am Urberg 21
49186 Bad Iburg
eMail: dr.f.j.kreutzer@t-online.de
