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Synthesis 2005(6): 1028-1029
DOI: 10.1055/s-2004-834856
DOI: 10.1055/s-2004-834856
PSP
© Georg Thieme Verlag Stuttgart · New York
A Large-Scale Low-Cost Access to the Lithium 2,2,6,6-Tetramethylpiperidide Precursor
Weitere Informationen
Received
15 June 2004
Publikationsdatum:
21. Oktober 2004 (online)
Publikationsverlauf
Publikationsdatum:
21. Oktober 2004 (online)
![](https://www.thieme-connect.de/media/synthesis/200506/lookinside/thumbnails/10.1055-s-2004-834856-1.jpg)
Abstract
Wolff-Kishner-Huang reduction of the cheap 2,2,6,6-tetramethyl-4-piperidinone (2) provides the expensive 2,2,6,6-tetramethylpiperidine (1), the precursor to lithium 2,2,6,6-tetramethylpiperidide, in high yield. As specified in the detailed protocol, the reaction can be conveniently carried out on a >10 mol laboratory scale.
Key words
continuous reaction - hydrazone dediazotation - lithium 2,2,6,6-tetramethylpiperidide - 2,2,6,6-tetramethylpiperidine - Wolff-Kishner reduction
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