A large number of novel 3-(heterocyclylsulfonyl)propanoic acids and their amide derivatives
were prepared in good yields and excellent purity starting from the corresponding
heterocyclic compounds. At first, chlorosulfonates were generated by reaction of initial
heterocycles with various sulfonating and chlorinating agents followed by their conversion
into sodium sulfinates. Treatment of sulfinates with acrylic acid smoothly afforded
a series of sulfonylpropionates, which were used as convenient reagents for the preparation
of a large number of the corresponding carboxamide derivatives.
3-(heterocyclylsulfonyl)propanoic acid - chlorosulfonates - heterocycles - parallel
synthesis - libraries
