Abstract
A total synthesis of naturally occurring 1-methoxycan-thin-6-one is described. In this synthesis, we achieved one-pot conversion from β-carboline-1-carbaldehyde to the canthin-6-one skeleton by the sequential addition of lithium ketene acetal in LiHMDS solution followed by the addition of EtOH in the reaction mixture.
Key words
indoles - β-carboline - alkaloids - aldol reaction - cyclization
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