An Efficient One-Pot Synthesis of Aminobenzimidazoles

David M. D. Fouchard; L. M. Viranga Tillekeratne; Richard A. Hudson

doi:10.1055/s-2004-834925

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Synthesis 2005(1): 17-18
DOI: 10.1055/s-2004-834925

SHORTPAPER

An Efficient One-Pot Synthesis of Aminobenzimidazoles

David M. D. Fouchard^a, L. M. Viranga Tillekeratne^a,b, Richard A. Hudson*^a,b
^a Department of Chemistry, College of Arts & Sciences, University of Toledo, Toledo, OH 43606, USA
^b Department of Medicinal & Biological Chemistry, College of Pharmacy, University of Toledo, Toledo, OH 43606, USA
Fax: +1(419)5307946; e-Mail: richard.hudson@utoledo.edu;

Further Information

Publication History

Received 28 June 2004
Publication Date:
17 November 2004 (online)

Abstract
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Abstract

An efficient one-pot procedure for the preparation of aminobenzimidazoles from dinitroaniline derivatives is described. The process helps to avoid the troublesome acetonitrile-mediated reductive ethylation reaction.

Key words

benzimidazoles - pyrroloquinoline quinines - reductive ethylation - bicyclic compounds - fused ring systems

References

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1

Current address: Department of Chemistry and Biochemistry, Montana State University (Gaines Hall, #328), Bozeman, MT 59715, USA.