Vasodilator Constituents from the Roots of Lysidice rhodostega

Abstract

Two new phloroglucinol glycosides, lysidisides A and B, and two new flavanol ramifycations, lysidicichin and mopanolside, together with (+)-mopanol, polydatin and E-resveratrol 3-O-β-D-xylopyranoside were isolated from the EtOAc extract of the roots of Lysidice rhodostega. The structures of the new compounds were elucidated on the basis of chemical and spectral evidence. Lysidisides A and B, (+)-mopanol and polydatin inhibited phenylepherine (Phe)-induced vasoconstriction in the rat aortic rings in the presences of indomethacin (Indo) and N^ω -L-nitroarginine (L-NA).

Abbreviations

Phe:phenylepherine

Ach:acetylcholine

Indo:indomethacin

L-NA:N^ω -L-nitroarginine

SNP:sodium nitroprusside

Lysidice rhodostega - Fabaceae - lysidiside - lysidicichin - mopanolside - endothelium-dependent vasodilation

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