Abstract
A stereoselective synthesis of substituted 1,3-dienes has been developed which utilises an Ireland-Claisen rearrangement/silicon-mediated fragmentation sequence. This sequence has been designed to introduce remote centres of asymmetry as well as stereodefined diene systems, and its application to an aziridine system is also described.
Key words
aziridine - Ireland-Claisen rearrangement - Sharpless asymmetric epoxidation - silicon-mediated fragmentation
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