Zusammenfassung
Die latente Hyperthyreose ist in Deutschland mit bis zu 6 % unendeckter Fälle die häufigste Schilddrüsenfunktionsstörung. Da sie oft mit einer nur diskreten Symptomatik einhergeht, wurde lange Zeit die Frage der Therapierelevanz diskutiert. Die vorliegende Arbeit zeigt zugrunde liegende zelluläre Effekte der latenten Hyperthyreose auf den Energiestoffwechsel und die Elektrophysiologie bzw. die Genexpression am Skelettmuskel und am Kardiomyozyten.
Abstract
Subclinical hyperthyroidism is the most frequent thyroid dysfunction in Germany and is estimated to account for about 6 % of the undiscovered functional thyroid disorders. Because subclinical hyperthyroidism often causes only less distinct symptoms therapeutic relevance was under debate for long time. The present overview shows the underlying cellular effects of the subclinical hyperthyroidism which influences the energy metabolism and the electrophysiology resp. the gene expression of skeletal muscle and heart.
Schlüsselwörter
latente Hyperthyreose - Energiestoffwechsel - Elektrophysiologie - Genexpression - Skelettmuskel - Herz
Key words
subclinical hyperthyroidism - energy metabolism - electrophysiology - gene expression - skeletal muscle - heart
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Dr. Peter Theissen
Klinik und Poliklinik für Nuklearmedizin der Universität zu Köln
Kerpener-Straße 62
50924 Köln
Phone: 02 21/4 78 58 56
Email: peter.theissen@uni-koeln.de