Latente Schilddrüsenfunktionsstörungen: Spezielle Diagnostik - pathophysiologische Aspekte bei latenter Hyperthyreose

P. Theissen; M. Schmidt; M. Dietlein; H. Schicha

doi:10.1055/s-2005-836762

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Der Nuklearmediziner 2005; 28(2): 80-85
DOI: 10.1055/s-2005-836762

Schilddrüse - Update 2005

Latente Schilddrüsenfunktionsstörungen: Spezielle Diagnostik - pathophysiologische Aspekte bei latenter Hyperthyreose

Subclinical Thyroid Dysfunction: Specific Diagnostics of Physiopathological Aspects in Subclinical HyperthyroidismP. Theissen¹ , M. Schmidt¹ , M. Dietlein¹ , H. Schicha¹

¹Klinik und Poliklinik für Nuklearmedizin der Universität zu Köln

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Publication Date:
27 July 2005 (online)

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Zusammenfassung

Die latente Hyperthyreose ist in Deutschland mit bis zu 6 % unendeckter Fälle die häufigste Schilddrüsenfunktionsstörung. Da sie oft mit einer nur diskreten Symptomatik einhergeht, wurde lange Zeit die Frage der Therapierelevanz diskutiert. Die vorliegende Arbeit zeigt zugrunde liegende zelluläre Effekte der latenten Hyperthyreose auf den Energiestoffwechsel und die Elektrophysiologie bzw. die Genexpression am Skelettmuskel und am Kardiomyozyten.

Abstract

Subclinical hyperthyroidism is the most frequent thyroid dysfunction in Germany and is estimated to account for about 6 % of the undiscovered functional thyroid disorders. Because subclinical hyperthyroidism often causes only less distinct symptoms therapeutic relevance was under debate for long time. The present overview shows the underlying cellular effects of the subclinical hyperthyroidism which influences the energy metabolism and the electrophysiology resp. the gene expression of skeletal muscle and heart.

Schlüsselwörter

latente Hyperthyreose - Energiestoffwechsel - Elektrophysiologie - Genexpression - Skelettmuskel - Herz

Key words

subclinical hyperthyroidism - energy metabolism - electrophysiology - gene expression - skeletal muscle - heart

Literatur

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Dr. Peter Theissen

Klinik und Poliklinik für Nuklearmedizin der Universität zu Köln

Kerpener-Straße 62

50924 Köln

Phone: 02 21/4 78 58 56

Email: peter.theissen@uni-koeln.de