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Klin Padiatr 2007; 219(1): 37-43
DOI: 10.1055/s-2005-836937
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© Georg Thieme Verlag Stuttgart · New York

Erstellung einer Kompatibilitätstabelle für die intravenöse Pharmakotherapie auf neonatologischen und pädiatrischen Intensivstationen

Preparation of a Compatibility Chart for Intravenous Drug Therapy in Neonatal and Pediatric Intensive Care UnitsJ.-H. Höpner1 , A. Schulte2 , J. Thiessen2 , M. Knuf1 , R. G. Huth1
  • 1Interdisziplinäre Pädiatrische Intensivstation, Kinderklinik und Poliklinik der Johannes-Gutenberg-Universität Mainz
  • 2Apotheke der Johannes-Gutenberg-Universität Mainz
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Publication History

Publication Date:
08 December 2005 (online)

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ErratumKlin Padiatr 2007; 219(06): 391-391
DOI: 10.1055/s-2007-993192

Zusammenfassung

Hintergrund: Moderne Intensivtherapie in Neonatologie und Pädiatrie beinhaltet eine differenzierte Pharmakotherapie mit zahlreichen Arzneimitteln, die überwiegend intravenös verabreicht werden. Trotz des Einsatzes von mehrlumigen Zentralvenenkathetern müssen häufig weitere Venenzugänge angelegt werden. Um einerseits die Anzahl der notwendigen venösen Zugänge zu vermindern, andererseits aber mit hoher Sicherheit Komplikationen durch Inkompatibilität der infundierten Arzneimittel zu vermeiden, wurde eine Kompatibilitätstabelle erstellt, deren Spektrum über das der bisher verfügbaren Tabellen hinausgeht. Methode: Informationen zur Kompatibilität häufig verordneter Medikamente wurden durch die Auswertung der Fachinformationen der Hersteller, gebräuchlicher Handbücher sowie eine Literaturrecherche gesammelt. Ergebnis: Für 78 in der neonatologischen und pädiatrischen Intensivtherapie gebräuchliche Arzneimittel wurden die verfügbaren Daten in Form einer tabellarischen Matrix dargestellt. Neben dem pH-Wert der Substanzen wurden die getesteten Arzneimittelkombinationen entsprechend ihrer In-/Kompatibilität bei simultaner Infusion kodiert. Bei der Kodierung wurde der Schwerpunkt auf eine hohe Sicherheit in der Therapie gelegt. Schlussfolgerung: Die Kompatibilitätstabelle bietet einen schnellen Überblick über die Datenlage zu Inkompatibilitäten bei der intravenösen medikamentösen Therapie.

Abstract

Background: Modern neonatal and pediatric intensive care includes a sophisticated pharmacotherapy with numerous drugs, mainly administered intravenously. Often, despite the use of multi-lumen central venous lines, more peripheral venous accesses are required. To reduce the necessity of numerous venous lines on one hand and on the other hand to avoid complications from incompatibilities of the administered drugs, we compiled a compatibility chart, encompassing more substances than covered in previously available charts. Methods: Information on compatibility of commonly prescribed drugs was collected by analysis of manufacturers' information, medical and pharmaceutical handbooks, and a literature research. Results: Available data on compatibility of 78 drugs were displayed in a two-dimensional chart. Beside the pH of each drug, compatibility of drug combinations was encoded for simultaneous infusion. Special emphasis was on security of the therapy. Conclusion: The compatibility chart gives quick reference for Data on compatibility of intravenously administered drugs in neonatal and pediatric intensive care.

Schlüsselworte

Inkompatibilität - intravenöse Infusionen - neonatologische Intensivmedizin - pädiatrische Intensivstation

Key words

drug incompatibility - infusions - intravenous - neonatal intensive care - intensive care units - pediatric

Literatur

  • 1 Akkerman S R, Zhang H, Mullins R E, Yaughn K. Stability of milrinone lactate in the presence of 29 critical care drugs and 4 i.v. solutions.  Am J Health Syst Pharm. 1999;  56 63-68
    PubMedSearch in Google Scholar
  • 2 Boullata J I, Gelone S P. More on usability of lorazepam admixtures for continuous infusion.  Am J Health Syst Pharm. 1996;  53 2754-2755
    PubMedSearch in Google Scholar
  • 3 Campbell S, Nolan P EJ, Bliss M, Wood R, Mayersohn M. Stability of amiodarone hydrochloride in admixtures with other injectable drugs.  Am J Hosp Pharm. 1986;  43 917-921
    PubMedSearch in Google Scholar
  • 4 Chiu M F, Schwartz M L. Visual compatibility of injectable drugs used in the intensive care unit.  Am J Health Syst Pharm. 1997;  54 64-65
    PubMedSearch in Google Scholar
  • 5 Colucci R D, Cobuzzi L E, Halpern N A. Visual compatibility of esmolol hydrochloride and various injectable drugs during simulated Y-site injection.  Am J Hosp Pharm. 1988;  45 630-632
    PubMedSearch in Google Scholar
  • 6 DeMonaco H J. Intravenous drug compatibility.  Crit Care Med. 1990;  18 896
    PubMedSearch in Google Scholar
  • 7 Forman J K, Souney P F. Visual compatibility of midazolam hydrochloride with common preoperative injectable medications.  Am J Hosp Pharm. 1987;  44 2298-2299
    PubMedSearch in Google Scholar
  • 8 Garabedian-Ruffalo S, Ruffalo R. Compatibilities and stabilities of iv preparations.  Crit Care Nurse. 1989;  9 81-85
    PubMedSearch in Google Scholar
  • 9 Gikic M, Di Paolo E R, Pannatier A, Cotting J. Evaluation of physicochemical incompatibilities during parenteral drug administration in a paediatric intensive care unit.  Pharm World Sci. 2000;  22 88-91
    PubMedSearch in Google Scholar
  • 10 Grillo J A, Gonzalez E R, Ramaiya A, Karnes H T, Wells B. Chemical compatibility of inotropic and vasoactive agents delivered via a multiple line infusion system.  Crit Care Med. 1995;  23 1061-1066
    PubMedSearch in Google Scholar
  • 11 Gura K M. Parenteral drug administration guidelines for the pediatric patient: one hospital's recommendations.  Hosp Pharm. 1993;  28 221-228, 231
    PubMedSearch in Google Scholar
  • 12 Hasegawa G R, Eder J F. Visual compatibility of dobutamine hydrochloride with other injectable drugs.  Am J Hosp Pharm. 1984;  41 949-951
    PubMedSearch in Google Scholar
  • 13 Hasegawa G R, Eder J F. Visual compatibility of amiodarone hydrochloride injection with other injectable drugs.  Am J Hosp Pharm. 1984;  41 1379-1380
    PubMedSearch in Google Scholar
  • 14 Horrow J C, Digregorio G J, Barbieri E J, Rupp E. Intravenous infusions of nitroprusside, dobutamine, and nitroglycerin are compatible.  Crit Care Med. 1990;  18 858-861
    PubMedSearch in Google Scholar
  • 15 Johnson C E, Bhatt-Mehta V, Mancari S C, McKown J A. Stability of midazolam hydrochloride and morphine sulfate during simulated intravenous coadministration.  Am J Hosp Pharm. 1994;  51 2812-2815
    PubMedSearch in Google Scholar
  • 16 Karnatz N N, Wong J, Kesler H, Baaske D M, Speicher E R. Compatibility of esmolol hydrochloride with morphine sulfate and fentanyl citrate during simulated Y-site administration.  Am J Hosp Pharm. 1988;  45 368-371
    PubMedSearch in Google Scholar
  • 17 Mantong M L, Marquardt E D. Visual compatibility of midazolam hydrochloride with selected drugs during simulated Y-site injection.  Am J Health Syst Pharm. 1995;  52 2567-2568
    PubMedSearch in Google Scholar
  • 18 Marquardt E D, Lam S S. Visual compatibility of fentanyl citrate with selected drugs during simulated Y-site injection.  Am J Hosp Pharm. 1994;  51 811-812
    PubMedSearch in Google Scholar
  • 19 Michaels M R, Stauffer G L, Haas D P. Propofol compatibility with other intravenous drug products: two new methods of evaluating IV emulsion compatibility.  Ann Pharmacother. 1996;  30 228-232
    PubMedSearch in Google Scholar
  • 20 Pecar A. Kompatibilitätstabelle. In: Nicolai T. Pädiatrische Notfall- und Intensivtherapie. 1. Aufl. Springer, Berlin, Heidelberg, New York 1999
  • 21 Poirier T I, Giudici R A. Evaluation of IV compatibility microcomputer software programs.  Hosp Pharm. 1991;  26 1037-1040
    PubMedSearch in Google Scholar
  • 22 Pugh C B, Pabis D J, Rodriguez C. Visual compatibility of morphine sulfate and meperidine hydrochloride with other injectable drugs during simulated Y-site injection.  Am J Hosp Pharm. 1991;  48 123-125
    PubMedSearch in Google Scholar
  • 23 Savitsky M E. Visual compatibility of neuromuscular blocking agents with various injectable drugs during simulated Y-site injection.  Am J Hosp Pharm. 1990;  47 820-821
    PubMedSearch in Google Scholar
  • 24 Schröder F. Kompatibilitätsprobleme in der Intensivmedizin.  Infusionsther Transfusionsmed. 1994;  21 52-58
    PubMedSearch in Google Scholar
  • 25 Servais H, Tulkens P M. Stability and compatibility of ceftazidime administered by continuous infusion to intensive care patients.  Antimicrob Agents Chemother. 2001;  45 2643-2647
    CrossrefPubMedSearch in Google Scholar
  • 26 Seto W, Trope A, Carfrae L, Walker S. Visual compatibility of sodium nitroprusside with other injectable medications given to pediatric patients.  Am J Health Syst Pharm. 2001;  58 1422-1426
    PubMedSearch in Google Scholar
  • 27 Smythe M, Malouf E. Visual compatibility of insulin with secondary intravenous drugs in admixtures.  Am J Hosp Pharm. 1991;  48 125-126
    PubMedSearch in Google Scholar
  • 28 Swart E L, Mooren R A, Loenen A C. Compatibility of midazolam hydrochloride and lorazepam with selected drugs during simulated Y-site administration.  Am J Health Syst Pharm. 1995;  52 2020-2022
    PubMedSearch in Google Scholar
  • 29 Thompson D F, Thompson G D. Visual compatibility of esmolol hydrochloride and furosemide in 5 % dextrose or 0.9 % sodium chloride injections.  Am J Hosp Pharm. 1987;  44 2740
    PubMedSearch in Google Scholar
  • 30 Tounian P, Jehl F, Pauliat S, Morgant G, Ghirardi L, Selva M A. et al . Stability and compatibility of teicoplanin in parenteral nutrition solutions used in pediatrics.  Clin Nutr. 1999;  18 159-165
    PubMedSearch in Google Scholar
  • 31 Treadway G. Clinical safety of intravenous amrinone -a review.  Am J Cardiol. 1985;  56 39 B-40 B
    PubMedSearch in Google Scholar
  • 32 Trissel L A, Gilbert D L, Martinez J F. Compatibility of propofol injectable emulsion with selected drugs during simulated Y-site administration.  Am J Health Syst Pharm. 1997;  54 1287-1292
    CrossrefPubMedSearch in Google Scholar
  • 33 Trissel L A. Handbook on Injectable Drugs. 12th ed. Nature Publishing Group, United Kingdom 2002
  • 34 Vermeire A, Remon J P, Schrijvers D, Demeulenaere P. A new method to obtain and present complete information on the compatibility: study of its validity for eight binary mixtures of morphine with drugs frequently used in palliative care.  Palliat Med. 2002;  16 417-424
    CrossrefPubMedSearch in Google Scholar
  • 35 Vogel Kahmann I, Bürki R, Denzler U, Höfler A, Schmid B, Spilsgardt H. Inkompatibilitätsreaktionen auf der Intensivstation.  Anaesthesist. 2003;  52 409-412
    CrossrefPubMedSearch in Google Scholar
  • 36 Wedekind C A, Fidler B D. Compatibility of commonly used intravenous infusions in a pediatric intensive care unit.  Crit Care Nurse. 2001;  21 45-51
    PubMedSearch in Google Scholar
  • 37 Yamashita S K, Walker S E, Choudhury T, Iazzetta J. Compatibility of selected critical care drugs during simulated Y-site administration.  Am J Health Syst Pharm. 1996;  53 1048-1051
    PubMedSearch in Google Scholar
  • 38 Zeller F P, Anders R J. Compatibility of intravenous drugs in a coronary intensive care unit.  Drug Intell Clin Pharm. 1986;  20 349-352
    PubMedSearch in Google Scholar

Dr. med. J.-H. Höpner

Interdisziplinäre pädiatrische Intensivstation · Kinderklinik und Poliklinik des Klinikum der Johannes-Gutenberg-Universität Mainz

Langenbeckstr. 1

55101 Mainz

Email: hoepner@kinder.klinik.uni-mainz.de