Coincidence of High Antiislet and Antithyroid Autoantibody Titles in First-Degree Relatives of Patients with Type 1 Diabetes

F. Sougioultzoglou; A. Falorni; G. Kassi; A. Brozzetti; D. Karamitsos; G. G. Koliakos

doi:10.1055/s-2005-837510

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2005; 113(2): 85-89
DOI: 10.1055/s-2005-837510

Article

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Coincidence of High Antiislet and Antithyroid Autoantibody Titles in First-Degree Relatives of Patients with Type 1 Diabetes

F. Sougioultzoglou¹ , A. Falorni² , G. Kassi² , A. Brozzetti² , D. Karamitsos¹ , G. G. Koliakos³

¹Diabetes Center, Hippokratio Hospital, Medical School, Aristotle University, Thessaloniki, Greece
²Department of Internal Medicine, Section of Internal Medicine and Endocrine & Metabolic Sciences, University of Perugia, Perugia, Italy
³Department of Biological Chemistry, Medical School, Aristotle University, Thessaloniki, Greece

Abstract

An association between thyroid and islet autoantibodies has been reported for patients with type 1 diabetes and their first-degree relatives. However no general agreement on this association has been reached since several studies reported controversial data. In the present study, sera from 429 healthy first-degree relatives of type 1 diabetic patients have been examined for the presence of thyroid and islet autoantibodies. Autoantibodies against glutamate decarboxylase (GAD65Ab) and tyrosine-phosphatase IA-2 (IA-2/ICA512Ab) have been detected by radioimmunoassay techniques with in vitro translated recombinant human ³⁵S-autoantigens. The presence of autoantibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) has been estimated by commercial radioimmunoassay kits. An increased frequency of TgAb was found in subjects who were positive for GAD65Ab (p = 0.0257). However, no significant association between TPOAb and GAD65Ab or IA-2Ab or between TgAb and IA-2Ab could be established. These data indicate an increased rate of coincidence between TgAb and GAD65Ab in healthy first-degree relatives of type 1 diabetic patients. Accordingly a common genetic background leading to the appearance of both TgAb and GAD65Ab may be suggested.

Key words

Type 1 diabetes - autoimmunity - thyroid - GAD65 antibodies - IA-2 antibodies

Full Text

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