Abstract
Sialadenosis, also referred to as sialosis, is a disease of unknown aetiology. It
regularly manifests itself as a massive swelling in both parotid regions involving
the major salivary glands, preferably the parotid glands and is characterized by lack
of any detectable, underlying pathologies. In this case report we describe a 24-year-old
white female patient with diabetes insipidus who developed sialadenosis of the major
salivary glands during a period of enhanced water requirement, which the patient tried
to compensate for by more frequent nasal ADH application. Since ADH acts on aquaporins
(AQPs) in the kidney, we were interested if AQP expression in the patients salivary
glands was affected. Surprisingly, compared to normal control tissues we observed
an extensively high signal for AQP5, which is the dominant AQP found in salivary acinar
cells. Interestingly, previous studies on AQP5 knock out mice found AQP5 to be required
for cell volume regulation. We therefore suggest that aquaporin water channels and
antidiuretic hormone together with a disturbance in the body's water household are
potential key-factors in the pathophysiological events leading to the development
of the disease entity called sialadenosis.
Key words
Aquaporin - AQP5 - ADH - sialadenosis - sialosis
References
1
Abrams C.
ADH-associated pathologies. Diabetes insipidus and syndrome of inappropriate ADH.
MLO Med Lab Obs.
2000;
32
24-28
2
Borgnia M, Nielsen S, Engel A, Agre P.
Cellular and molecular biology of the aquaporin water channels.
Annu Rev Biochem.
1999;
68
425-458
3
Denker B M, Smith B L, Kuhajda F P, Agre P.
Identification, purification, and partial characterization of a novel Mr 28 000 integral
membrane protein from erythrocytes and renal tubules.
J Biol Chem.
1988;
263
15634-15642
4
Donath K.
(Swellings of the cheek from sialosis [author's transl]).
HNO.
1979;
27
113-118 (German)
5
Donath K, Seifert G.
Ultrastructural studies of the parotid glands in sialadenosis.
Virchows Arch A Pathol Anat Histol.
1975;
365
119-135
6
Fujisawa I, Murakami N, Furuto-Kato S, Araki N, Konishi J.
Plasma and neurohypophyseal content of vasopressin in diabetes mellitus.
J Clin Endocrinol Metab.
1996;
81
2805-2809
7
Harding A J, Halliday G M, Ng J L, Harper C G, Kril J J.
Loss of vasopressin-immunoreactive neurons in alcoholics is dose-related and time-dependent.
Neurosci.
1996;
72
699-708
8
Henry-Stanley M J, Beneke J, Bardales R H, Stanley M W.
Fine-needle aspiration of normal tissue from enlarged salivary glands: sialosis or
missed target?.
Diagn Cytopathol.
1995;
13
300-303
9
Krane C M, Melvin J E, Nguyen H V, Richardson L, Towne J E, Doetschman T, Menon A G.
Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water
permeability and altered cell volume regulation.
J Biol Chem.
2001;
276
23413-23420
10
Lee M D, Bhakta K Y, Raina S, Yonescu R, Griffin C A, Copeland N G, Gilbert D J, Jenkins N A,
Preston G M, Agre P.
The human aquaporin-5 gene. Molecular characterization and chromosomal localization.
J Biol Chem.
1996;
271
8599-8604
11
Mandel L, Patel S.
Sialadenosis associated with diabetes mellitus: a case report.
J Oral Maxillofac Surg.
2002;
60
696-698
12 Seifert G. Oralpathologie I. Berlin, Heidelberg, New York; Springer 1996
13
Steinfeld S, Cogan E, King L S, Agre P, Kiss R, Delporte C.
Abnormal distribution of aquaporin-5 water channel protein in salivary glands from
Sjogren's syndrome patients.
Lab Invest.
2001;
81
143-148
Dr. Robert Mandic
Department of Otolaryngology, Head and Neck Surgery · Philipps University Marburg
Deutschhausstraße 3
35037 Marburg
Germany
Telefon: + 4964212862420
Fax: + 49 6 42 12 86 24 21
eMail: mandic@med.uni-marburg.de