The First Three Years of the Swiss Neuropaediatric Stroke Registry (SNPSR): A Population-Based Study of Incidence, Symptoms and Risk Factors

M. Steinlin; I. Pfister; J. Pavlovic; R. Everts; E. Boltshauser; A. Capone Mori; D. Gubser Mercati; C.-A. Hänggeli; E. Keller; J. Luetschg; J. Marcoz; G.-P. Ramelli; E. Roulet Perez; T. Schmitt-Mechelke; M. Weissert; null The Swiss Societies of Paediatric Neurology and Neonatology

doi:10.1055/s-2005-837658

Neuropediatrics, Table of Contents

Neuropediatrics 2005; 36(2): 90-97
DOI: 10.1055/s-2005-837658

Original Article

Georg Thieme Verlag KG Stuttgart · New York

The First Three Years of the Swiss Neuropaediatric Stroke Registry (SNPSR): A Population-Based Study of Incidence, Symptoms and Risk Factors

M. Steinlin¹ , I. Pfister¹ , J. Pavlovic¹ , R. Everts¹ , E. Boltshauser¹ , A. Capone Mori¹ , D. Gubser Mercati¹ , C.-A. Hänggeli¹ , E. Keller¹ , J. Luetschg¹ , J. Marcoz¹ , G.-P. Ramelli¹ , E. Roulet Perez¹ , T. Schmitt-Mechelke¹ , M. Weissert¹ , The Swiss Societies of Paediatric Neurology and Neonatology¹

¹Neuropaediatric Divisions of the Children's Hospitals in Bern, Zürich, Aarau, Neuchâtel, Geneva, Basle, Chur, Bellinzona, Lausanne, Lucerne, Sion, St. Gallen, Switzerland

Abstract

We report the results of three years of the population-based, prospective Swiss NeuroPaediatric Stroke Registry (SNPSR) of children (up to 16 years) with childhood arterial ischaemic stroke (AIS1), neonatal stroke (AIS2), or symptomatic sinus venous thrombosis (SVT). Data on risk factors (RF), presentation, diagnostic work-up, localisation, and short-term neurological outcome were collected. 80 children (54 males) have been included, 40 AIS1, 23 AIS2, and 17 SVT. The data presented will be concentrated on AIS. The presentation for AIS1 was hemiparesis in 77 % and cerebellar symptoms and seizures in 20 %, respectively. AIS2 presented in 83 % with seizures and in 38 % with abnormality of muscle tone. Two or more RF were detected in 54 %, one RF in 35 %. The most prominent RF for AIS1 were infections (40 %), followed by cardiopathies and coagulopathies (25 % each). AIS2 were frequently related to birth problems. Neurological outcomes in AIS1 and AIS2 were moderate/severe in 45 % and 32 %, respectively. The outcome correlated significantly with the size of infarction (p = 0.013) and age at stroke (p = 0.027). The overall mortality was 6 %. Paediatric stroke is a multiple risk problem, which leads to important long-term sequelae.

Key words

Paediatric stroke - epidemiology - manifestation - risk factors - outcome

Full Text

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MD Maja Steinlin

Division of Paediatric Neurology
University Children's Hospital
Inselspital

Freiburgstrasse

3010 Bern

Switzerland

Email: maja.steinlin@insel.ch