Planta Med 2005; 71(1): 72-76
DOI: 10.1055/s-2005-837754
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Four New 6-Nor-5(6→7)abeo-abietane Type Diterpenes and Antitumoral Cytotoxic Diterpene Constituents from the Bark of Taiwania cryptomerioides

Chi-I Chang1 , Jang-Yang Chang2 , Ching-Chuan Kuo2 , Wen-Yu Pan2 , Yueh-Hsiung Kuo3
  • 1Graduate Institute of Biotechnology, National Pingtung University of Science and Technology, Pingtung, Taiwan
  • 2Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan
  • 3Department of Chemistry, National Taiwan University, Taipei, Taiwan
Further Information

Publication History

Received: March 12, 2004

Accepted: September 6, 2004

Publication Date:
27 January 2005 (online)

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Abstract

Four new 6-nor-5(6→7)abeo-abietane type diterpenes designated as taiwaniaquinone G, taiwaniaquinone H, taiwaniaquinol E and taiwaniaquinol F and eight known diterpenes, taiwaniaquinones A (5), D (6), E, F (8), and taiwaniaquinols A (9), B, C (11), D (12) were isolated from the bark of Taiwania cryptomerioides. Their structures were elucidated on the basis of spectroscopic studies. These twelve diterpenes were evaluated for in vitro antitumoral cytotoxic activity. The result demonstrated that compounds 5, 6, 8, 9, 11, and 12 bearing an aldehyde group possessed potent cytotoxic activity against KB epidermoid carcinoma cancer cell lines with IC50 values of 6.9, 7.2, 4.4, 8.3, 8.1, and 3.5 μM, respectively.

References

Professor Yueh-Hsiung Kuo

Department of Chemistry

National Taiwan University

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