Four New 6-Nor-5(6→7)abeo-abietane Type Diterpenes and Antitumoral Cytotoxic Diterpene Constituents from the Bark of Taiwania cryptomerioides

Chi-I. Chang; Jang-Yang Chang; Ching-Chuan Kuo; Wen-Yu Pan; Yueh-Hsiung Kuo

doi:10.1055/s-2005-837754

Planta Medica, Table of Contents

Planta Med 2005; 71(1): 72-76
DOI: 10.1055/s-2005-837754

Original Paper

Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Four New 6-Nor-5(6→7)abeo-abietane Type Diterpenes and Antitumoral Cytotoxic Diterpene Constituents from the Bark of Taiwania cryptomerioides

Chi-I Chang¹ , Jang-Yang Chang² , Ching-Chuan Kuo² , Wen-Yu Pan² , Yueh-Hsiung Kuo³

¹Graduate Institute of Biotechnology, National Pingtung University of Science and Technology, Pingtung, Taiwan
²Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan
³Department of Chemistry, National Taiwan University, Taipei, Taiwan

Abstract

Four new 6-nor-5(6→7)abeo-abietane type diterpenes designated as taiwaniaquinone G, taiwaniaquinone H, taiwaniaquinol E and taiwaniaquinol F and eight known diterpenes, taiwaniaquinones A (5), D (6), E, F (8), and taiwaniaquinols A (9), B, C (11), D (12) were isolated from the bark of Taiwania cryptomerioides. Their structures were elucidated on the basis of spectroscopic studies. These twelve diterpenes were evaluated for in vitro antitumoral cytotoxic activity. The result demonstrated that compounds 5, 6, 8, 9, 11, and 12 bearing an aldehyde group possessed potent cytotoxic activity against KB epidermoid carcinoma cancer cell lines with IC₅₀ values of 6.9, 7.2, 4.4, 8.3, 8.1, and 3.5 μM, respectively.

Key words

Taiwania cryptomerioides - Taxodiaceae - diterpenes, 6-nor-5(6→7)abeo-abietane - cytotoxic activity

Full Text

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Professor Yueh-Hsiung Kuo

Department of Chemistry

National Taiwan University

Taipei

Taiwan 106

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Email: yhkuo@ccms.ntu.edu.tw