Antitubercular Constituents from the Roots of Engelhardia roxburghiana

Abstract

Three new compounds, engelhardione, (-)-5-hydroxy-4-methoxy-1-tetralone, and 3-methoxycarbonyl-1,5-dihydroxyanthraquinone, together with twelve known compounds have been isolated from the roots of Engelhardia roxburghiana. The structures of these new compounds were determined through spectral analyses. Engelhardione, 3-methoxyjuglone, and (-)-4-hydroxy-1-tetralone showed antitubercular activities with MIC values = 3.125, 3.125, and 6.25 μg/mL against Mycobacterium tuberculosis 90 - 221 387, respectively, and with MIC values = 0.2, 0.2, and 4.0 μg/mL against M. tuberculosis H37Rv, individually.

Key words

Engelhardia roxburghiana - Juglandaceae - root - engelhardione - (-)-5-hydroxy-4-methoxy-1-tetralone - 3-methoxycarbonyl-1,5-dihydroxyanthraquinone - antitubercular activities

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