Zusammenfassung
In dieser Übersicht werden die ophthalmologischen Krankheitsbilder, die durch Herpes-simplex-Viren, Varicella-zoster-Viren, Epstein-Barr-Viren, Cytomegalieviren und Adenoviren verursacht werden, kurz beschrieben. Die wesentlichen therapeutischen Möglichkeiten werden insbesondere unter Berücksichtigung prospektiv randomisierter Studien beschrieben.
Abstract
In this review ophthalmological diseases caused by herpes simplex virus, varicella zoster virus, Epstein-Barr virus, cytomegaly virus or adenovirus are described briefly. The main therapeutic options are discussed placing emphasis especially on prospective randomised trials.
Schlüsselwörter
Virostatika - Herpes-simplex-Viren - Varicella-zoster-Viren - Epstein-Barr-Viren - Cytomegalieviren - Adenoviren - Keratitis - Uveitis - Retinits
Key words
Antivirals - herpes simplex virus - varicella zoster virus - Epstein-Barr virus - cytomegaly virus - adenovirus - keratitis - uveitis - retinitis
Literatur
-
1
Ahmed I, Ai E.
Medical management of cytomegalovirus retinitis.
Ophthalmol Clin North Am.
1997;
10
15-25
-
2
Akler M E, Johnson D W, Burman W J. et al .
Anterior uveitis and hypotony after intravenous cidofovir for the treatment of cytomegalovirus retinitis.
Ophthalmology.
1998;
105
651-657
-
3
Ameye C, Sundmacher R, De Clerq E.
Topical BVDU plus low-dosage steroids in the treatment of chronic relapsing zoster keratouveitis. A pilot study.
Graefe’s Arch Clin Exp Ophthalmol.
1989;
227
118-122
-
4
Barron B A, Gee L, Hauck W W. et al .
Herpetic Eye Disease Study. A controlled trial of oral acyclovir for herpes simplex stromal keratitis.
Ophthalmology.
1994;
101
1871-1882
-
5
Behrens-Baumann W, Weber U, Ansorg R.
Aciclovir und bakterielle Hornhautinfektion. Eine tierexperimentelle Studie.
Ber Dtsch Ophthalmol Ges.
1981;
78
399-401
-
6
Behrens-Baumann W.
Phosphonoformate (Foscarnet, PFA) versus trifluorthymidine in the treatment of keratitis dendritica in the human. A double-blind, randomized, preliminary trial.
Acta Ophthalmol.
1992;
70
690-692
-
7
Centifanto-Fitzgerald Y M, Fenger T, Kaufman H E.
Virus proteins in herpetic keratitis.
Exp Eye Res.
1982;
35
425-441
-
8
Centifanto-Fitzgerald Y M, Yamaguchi T, Kaufman H E. et al .
Ocular disease pattern induced by herpes simplex virus is genetically determined by specific region of viral DNA.
J Exp Med.
1982;
155
475-489
-
9
Chodosh J, Astley R A, Butler M G. et al .
Adenovirus keratitis: A role for interleukin-8.
Invest Ophthalmol Vis Sci.
2000;
41
783-789
-
10 Cohen E J, Rapuano C J, Laibson P R. External Diseases. Tasman W, Jaeger EA The Wills Eye Hospital atlas of clinical ophthalmology Philadelphia, USA; Lippincott-Raven Publishers 1996: 17-19
-
11
Colin J, Hoh H B, Easty D L. et al .
Ganciclovir ophthalmic gel (Virgan; 0,15 %) in the treatment of herpes simplex keratitis.
Cornea.
1997;
16
393-399
-
12
Collum L M, Logan P, Ravenscroft T.
Acyclovir in herpetic disciform keratitis.
Br J Ophthalmol.
1983;
67
115-117
-
13
Collum L M, McGettrick P, Akhtar J. et al .
Oral acyclovir in herpes simplex dendritic corneal ulceration.
Br J Ophthalmol.
1986;
70
435-438
-
14
Corey L, Whitley R J, Stone E F. et al .
Difference between herpes simplex virus type 1 and type 2 neonatal encephalitis in neurological outcome.
Lancet.
1988;
January 2
1-4
-
15
Crouse C A, Pflugfelder S C, Pereira I. et al .
Detection of herpes viral genomes in normal and diseased corneal epithelium.
Curr Eye Res.
1990;
9
569-581
-
16
Culbertson W W, Blumenkranz M S, Pepose J S. et al .
Varicella zoster virus is a cause of the acute retinal necrosis syndrome.
Ophthalmology.
1986;
93
559-569
-
17
Culbertson W W, Atherton S S.
Acute retinal necrosis and similar retinitis syndromes.
Ophthalmology.
1993;
33
129-143
-
18 Culbertson W W, Dix R D. Varicella-Zoster Virus diseases: Posterior Segment of the Eye. Pepose JS, Holland GN, Williams KR Ocular Infection and Immunology St Louis, USA; Mosby 1996: 1131-1154
-
19
Dawson C R, Togni B.
Herpes simplex eye infections. Clinical manifestation, pathogenesis and management.
Surv Opthalmol.
1976;
21
121-135
-
20
Engstrom R E Jr, Holland G N, Margolis T P. et al .
The progressive outer retinal necrosis syndrome: a variant of necrotizing herpetic retinopathy in patients with AIDS.
Ophthalmology.
1994;
101
1488-1502
-
21
Gerling J, Neumann-Haefelin D, Seuffert H M. et al .
Diagnosis and management of the acute reinal necrosis syndrome.
Ger J Ophthalmol.
1992;
1
388-393
-
22
Günther R.
Pathologisch-anatomischer Befund einer Hornhaut bei Keratitis epidemica.
Klin Monatsbl Augenheilk.
1939;
103
309-314
-
23
Hansen L L.
Retinale Erkrankungen bei AIDS.
Ophthalmologe.
1993;
90
239-249
-
24
Hansen L L.
HIV-Infektion und Auge.
Ophthalmologe.
2000;
97
718-736
-
25
Herpetic Eye Disease Study Group .
A controlled trial of topical corticosteroids for herpes simplex stromal keratitis.
Ophthalmology.
1994;
101
1883-1895
-
26
Herpetic Eye Disease Study Group .
A controlled trial of oral acyclovir for iridocyclitis caused by herpes simplex virus.
Arch Ophthalmol.
1996;
114
1065-1072
-
27
Herpetic Eye Disease Study Group .
Acyclovir for the prevention of recurrent herpes simplex virus eye disease.
N Engl J Med.
1998;
339
340-341
-
28
Hillenkamp J, Reinhard T, Ross R S. et al .
Topical treatment of acute adenoviral keratoconjunctivitis with 0.2 % Cidofovir and 1 % Cyclosporin A: A controlled clinical pilot study.
Arch Ophthalmol.
2001;
109
845-850
-
29
Hillenkamp J, Reinhard T, Ross R S. et al .
The effects of Cidofovir 1 % with and without Cyclosporin A 1 % as a topical treatment of acute adenoviral keratoconjunctivitis. A controlled clinical pilot study.
Ophthalmology.
2002;
109
845-850
-
30
Hoh H B, Hurley C, Claoue C. et al .
Randomised trial of ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis: a multicentre study.
Br J Ophthalmol.
1996;
80
140-142
-
31 Holland E J, Mozayeni R M, Schwartz G S. Herpes simplex keratitis. Krachmer JH, Mannis MJ, Holland EJ Cornea. St Louis, Missouri, USA; Mosby 1997: 1191-1223
-
32
Holland G N.
Executive committee of the American uveitis society. Standard diagnostic criteria for the acute retinal necrosis syndrome.
Am J Ophthalmol.
1994;
117:
663-667
-
33
Kaufman H E, Centifanto-Fitzgerald Y M, Varnell E D.
Herpes simplex keratitis.
Ophthalmology.
1983;
90
700-706
-
34
Kersten A, Reinhard T, Sundmacher R.
Postoperative Komplikationen nach perforierender Keratoplastik in Herpesaugen.
Ophthalmologe.
1997;
94
889-896
-
35
Lalezari J P.
Cidofovir: a new therapy for cytomegalovirus retinitis.
J Acqu Imm Def Syndr Hum Retrovirol.
1997;
14 (S1)
22-26
-
36 Liesegang T J. Herpes zoster keratitis. Krachmer JH, Mannis MJ, Holland EJ Cornea. St Louis, Missouri, USA; Mosby 1997: 1225-1242
-
37
Lund O E, Stefani F H.
Corneal histology after epidemic keratoconjunctivitis.
Arch Ophthalmol.
1978;
96
2085-2088
-
38 Margolis T P, Atherton S S. Herpes simplex virus diseases: posterior segment of the eye. Pepose JS, Holland GN, Williams KR Ocular Infection and Immunology St Louis, USA; Mosby 1996: 1155-1167
-
39
Maugdal P C, De Clerq E, Missotten L.
Efficacy of bromovinyldeoxyuridine in the treatment of herpes simplex virus and varicella zoster virus in eye infections.
Antiviral Res.
1984;
4
281-291
-
40 Maugdal P C, Dieltiens M, De Clerq E. et al .Topical Bromovinyldeoxyuridine treatment of herpes simplex keratitis. Maugdal PC, Missotten L Herpetic eye diseases Dordrecht; Junk 1985: 247-255
-
41
Mayer K, Reinhard T, Reis A. et al .
Synergistic effect of acyclovir and mycophenolate mofetil following keratoplasty in patients with herpetic eye disease.
Graefe’s Arch Clin Exp Ophthalmol.
2003;
241
1051-1054
-
42
Nahmias A J, Visintine A M, Caldwell D R. et al .
Eye infections with herpes simplex viruses in neonates.
Surv Ophthalmol.
1976;
21
100-105
-
43
Neoh C, Harding S P, Saunders D. et al .
Comparison of topical and oral acyclovir in early herpes zoster ophthalmicus.
Eye.
1994;
8
688-691
-
44
Palay D A, Sternberg P Jr, Davis J. et al .
Decrease in the risk of bilateral acute retinal necrosis by acyclovir therapy.
Am J Ophthalmol.
1991;
112
250-255
-
45
Reinhard T, Godehadt E, Pfahl H G. et al .
Lokales Cyclosporin A bei Nummuli nach Keratoconjunktivitis epidemica. Eine Pilotstudie.
Ophthalmologe.
2000;
97
764-768
-
46
Reinhard T, Reis A, Mayweg S. et al .
Lokales FK506 bei entzündlichen Erkrankungen von Hornhaut und Bindehaut.
Klin Monatsbl Augenheilk.
2002;
219
125-131
-
47
Reinhard T, Adams O, Sundmacher R.
Detection of the Epstein-Barr virus genome in the anterior chamber of a patient with chronic uveitis.
Acta Ophthalmol.
2003;
81
671-673
-
48
Rossa V, Sundmacher R.
Lokale Interferonprophylaxe einer „epidemischen” Konjunktivitis durch ein nicht identifizierbares Virus.
Klin Monatsbl Augenheilk.
1991;
199
192-194
-
49
Smeraglia R, Hoachadel J, Varnell E D. et al .
The role of herpes simplex virus secreted glycoproteins in herpetic keratitis.
Exp Eye Res.
1982;
35
443-459
-
50
Sundmacher R, Neumann-Haefelin D, Cantell D.
Interferon treatment of dendritic keratitis.
Lancet.
1976;
I
1406
-
51
Sundmacher R, Cantell K, Haug P. et al .
Role of debridement and interferon in the treatment of dendritic keratitis.
Graefe’s Arch Clin Exp Ophthalmol.
1978;
207
77-82
-
52 Sundmacher R, Neumann-Haefelin D, Cantell K. Trials with interferon in ophthalmic zoster. Sundmacher R Herpetische Augenerkrankungen München; Bergmann Verlag 1981: 465-468
-
53 Sundmacher R. A clinico-virologic classification of herpetic anterior segment diseases with special reference to intraocular herpes. Sundmacher R Herpetische Augenerkrankungen München; Bergmann Verlag 1981: 203-210
-
54
Sundmacher R.
Orale Acyclovir-Theapie von i. o. Herpes simplex Virus Infektionen.
Klin Monatsbl Augenheilk.
1983;
183
246-250
-
55
Sundmacher R.
Therapie der herpetischen Erkrankungen des vorderen Augenabschnitts.
Klin Monatsbl Augenheilk.
1985;
186
421-425
-
56
Sundmacher R, Engelskirchen U.
Zum Problem der rezidivierenden und persistierenden Numuli nach Keratoconjunctivitis epidemica.
Klin Monatsbl Augenheilk.
1991;
198
550-554
-
57
Sundmacher R, Hillenkamp J, Reinhard T.
Perspektiven von Therapie und Prophylaxe der Adenoviruskeratokonjunktivitis.
Ophthalmologe.
2001;
98
991-1009
-
58 Stamler J F. Viral conjunctivitis. Krachmer JH, Mannis MJ, Holland EJ Cornea. St. Louis, Missouri, USA; Mosby 1997: 773-777
-
59
Trauzettel-Klosinski S, Sundmacher R, Wigand R.
Die Wirkung von Steroiden bei Keratoconjunctivitis epidemica.
Klin Monatsbl Augenheilk.
1980;
176
899-906
-
60
Tsai C S, Ritch R, Straus S E. et al .
Antibodies to Epstein-Barr virus in iridocorneal endothelial syndrome.
Arch Ophthalmol.
1990;
108
1572-1576
-
61
Uruyama A, Yamada N, Sasaki T. et al .
Unilateral acute uveitis with retinal periarteritis and detachment.
Jpn Clin Ophthalmol.
1971;
25
607-629
-
62
Wander A H, Centifanto Y M, Kaufman H E.
Strain specifity of clinical isolates of herpes simplex virus.
Arch Ophthalmol.
1980;
98
1458-1461
-
63
Wilhelmus K R.
Interventions for herpes simplex virus epithelial keratitis.
The Cochrane database of systematic reviews.
2004;
-
64
Zimmer C, Nieuwenhuis I, Danisevskis M. et al .
Plötzliche Erblindung bei einem AIDS-Patienten.
Klin Mbl Augenheilk.
1991;
199
48-52
Prof. Dr. T. Reinhard
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