Genetics of Type 2 Diabetes: Impact of Interleukin-6 Gene Variants

Zusammenfassung

Die KORA-Studien bieten eine hervorragende Basis, um komplexe Erkrankungen wie Typ-2-Diabetes oder das metabolische Syndrom auf genetischer Ebene zu analysieren. In diesen Studien wurden mehr als 2000 Typ-2-Diabetiker identifiziert, von denen DNA für genetische Analysen zur Verfügung steht. Bisher stand die Analyse von Genen im Vordergrund, die an der Inflammationsantwort beteiligt sind. Interleukin-6 (IL-6) als zentraler Mediator der Akutphase-Reaktion ist von Interesse. Erhöhte IL-6-Proteinkonzentrationen im Blut können die Entstehung von Typ-2-Diabetes vorhersagen. Da der Einfluss einer DNA-Variante im Promotor des Interleukin-6-Gens bisher nicht in einer populationsbasierten Studie untersucht wurde, analysierten wir die Assoziation des Einzelnukleotidbasenaustausches (SNPs) C-174G in einer Fall-Kontroll-Studie mit 704 älteren Probanden des KORA-Surveys S4 (1999/2001). Das Allel - 174G zeigte eine Tendenz zur Assoziation mit Typ-2-Diabetes (- 174G: OR 1,20, 95 %-KI 0,90 - 1,59, p = 0,21).

Abstract

The KORA studies serve as a powerful tool for the genetic analysis of complex diseases like type 2 diabetes or the metabolic syndrome. These studies include more than 2,000 prevalent and incident type 2 diabetes cases. DNA of these patients is available to be used in genetic studies. Up to now the analyses have focussed on genes coding for proteins being involved in the inflammatory response. Interleukin-6 (IL-6) as the key mediator of the acute phase reaction is of interest. Elevated protein concentrations of IL-6 in the blood have been shown to predict type 2 diabetes. We investigated the association of the IL-6 single nucleotide polymorphism (SNP) C-174G with type 2 diabetes in a case-control study of 704 elderly participants of the KORA Survey S4 (1999/2001).

When BMI, HDL cholesterol, physical activity, hypertension, hormone replacement therapy and smoking were considered as covariables the SNP C-174G showed a trend for association with type 2 diabetes (- 174G: OR 1.20, 95 % CI 0.90 - 1.59, p = 0.21).

Biologische Materialien - genetische Epidemiologie - MONICA/KORA - Typ-2-Diabetes - metabolisches Syndrom

Biological materials - genetic epidemiology - MONICA/KORA - type 2 diabetes

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