Polymyositis mit Anti-Jo-1-Antikörpern - 2 Kasuistiken zur erfolgeichen Therapie mit Leflunomid und ein aktueller Überblick

Zusammenfassung

Die idiopathischen Myositiden (IM), wie die Dermatomyositis (DM) und die Polymyositis (PM), sind wichtige Vertreter erworbener entzündlicher Muskelerkrankungen mit unbekannter Ätiologie. Antisynthetase-Antikörper wie Anti-Jo-1 sind hierbei hochspezifische myositisassoziierte Antikörper. Patienten mit Antisynthestase-Antikörper haben häufig eine Mitbeteiligung innerer Organe wie eine interstitielle Lungenerkrankung, Fieber, Polyarthritis, Myositis, Raynaud-Syndrom und „mechanic’s hands”. In der Therapie werden Immunsuppressiva eingesetzt. Geschildert werden zwei Fälle mit Polymyositis und Nachweis von Anti-Jo-1-Antikörper, die mit Leflunomid erfolgreich therapiert wurden. Zudem wird eine aktuelle Übersicht gegeben.

Abstract

Idiopathic inflammatory myopathies (IM), including dermatomyositis (DM) and polymyositis (PM), are a group of systemic rheumatological diseases of unknown etiology, characterized by a chronic inflammatory myositis. Antisynthetase antibodies like anti-Jo-1 antibody are known to be highly specific for inflammatory myopathies. Patients with this antibody often exhibit the combination of symptoms, including interstitial lung disease, fever, polyarthritis, inflammatory myositis, Raynaud’s phenomenon and “mechanic’s hands”. In the management of polymyositis with anti-Jo-1 antibody, immunosuppressive agents are used to control the disease. However, in treatment-resistant cases our experience with drug therapy is very limited. We now report on two female patients with polymyositis and anti-Jo-1 antibody who were successfully treated with leflunomide, and present a current overview of the literature.

Schlüsselwörter

Polymyositis - Anti-Jo-1-Antikörper - Leflunomid

Key words

Polymyositis - anti-Jo-1 antibody - leflunomide

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