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DOI: 10.1055/s-2005-861157
RNA Interference-based Strategies for Metabolic Syndrome Treatment
Publikationsverlauf
Received 4 January 2005
Accepted after revision 4 January 2005
Publikationsdatum:
21. März 2005 (online)


Abstract
RNA interference is a naturally occurring cellular mechanism to inhibit the expression of specific gene products. The technical application of RNA interference offers great potential for the specific treatment of a huge variety of diseases including the metabolic syndrome, one of the most challenging threats to human health associated with our civilization. In order to develop novel and powerful strategies for the treatment of the metabolic syndrome, it is essential to define a set of specific gene products that may be targeted by RNA interference. Based on currently available in vitro and in vivo data, we discuss the feasibility of candidate genes involved in the pathophysiology of the metabolic syndrome as potential targets for a rational RNA interference based therapy in this review.
Key words
Metabolic syndrome - Insulin signaling - Hepatic glucose production - Adipose tissue - Renin-angiotensin-aldosterone system