Der Zusammenhang zwischen Haut und Seele hat in der Forschung in den letzten Jahren einen entscheidenden Wandel erfahren: aus einer beschreibenden und psychosomatischen Sicht entwickelten sich ein moderner Forschungszweig, die Psychoneuroimmunologie. Auf der Basis einer gemeinsamen „Sprache” erfolgt ein bidirektionaler Informationsaustausch zwischen Gehirn und Peripherie. Ermöglicht wird dieser durch die bislang noch unvollständig charakterisierten lokalen neuroendokrinen Systeme, zu denen u. a. das extraneuronale cholinerge System, die antidrome Antwort oder lokal in Haarfollikeln vorhandene Komponenten der HPA-Achse gehören. Am Beispiel psychosomatisch relevanter Hauterkrankungen wird das Konzept einer neuroendokrin balancierten Immunmodulation entwickelt in dem die Haut-Gehirn Interaktion eine besondere Rolle spielt und ein Ausblick auf interessante Forschungsansätze gegeben.
Abstract
In recent years the scientific viewpoint on the relationship between skin and soul has transformed from a phenomenological and psychosomatic factor to a modern research branch, the psychoneuroimmunology. On the basis of a common “language” brain and peripheral organs exchange information bidirectionally. This is made possible by hitherto incompletely characterized local neuroendocrine systems, among which the extraneuronal cholinergic system, the antidromic response or components of the HPA-axis present in hair follicles play crucial parts. Taking psychosomatically relevant skin disorders as examples, we develop the concept of a neuroendocrine balanced immune-modulation in which skin-brain interaction plays a major role for future research projects.
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