Abstract
This study was conducted to assess the influence of dopamine on thyrotropin secretion
in patients with primary hypothyroidism before and after optimized L-thyroxin replacement
therapy. Thyrotropin responses to dopamine infusion (4 µg/kg/min over 3 hours) and
IV metoclopramide (10 mg bolus), a dopamine receptor blocker were studied in 25 consecutive
patients with primary hypothyroidism before and after achieving stable euthyroid state
and compared with 15 normal age-matched controls. Thyrotropin response to both dopamine
infusion (decremental) and IV metoclopramide bolus (incremental) was greater in patients
with primary hypothyroidism than that in the control subjects. Thyrotropin response
was greater in women than in men. The magnitude of decremental thyrotropin response
to dopamine infusion and the incremental response to IV metoclopramide bolus significantly
correlated with the basal T3 and T4 levels. Thyrotropin response was blunted to dopamine infusion but not to metoclopramide
at follow-up after six-month replacement with L-thyroxin, and both the responses were
comparable in women and men in patient group. We conclude that modulation of dopaminergic
system by dopamine or by dopamine receptor blocker has a greater influence on thyrotropin
secretion in patients with primary hypothyroidism than euthyroid normal subjects.
Key words
Dopamine - Metoclopramide - Primary hypothyroidism - Thyrotropin
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Dr. Anil Bhansali
Dept. of Endocrinology · Postgraduate Institute of Medical Education and Research
·
Chandigarh-160012 · India
Telefon: + 91 (172) 74 75 85-600, ext. 65 83
Fax: + 91 (172) 74 44 01, 74 50 78 ·
eMail: anilbhansali_endocrine@rediffmail.com
